| Model | Year | Engine power | Displacement | Top speed | 0-100 km/h (0-62 mph) |
|---|---|---|---|---|---|
| Mercedes-Benz S 350 CDi 4Matic L | 2011 | 174 kW | 2987 ccm | 250 km/h | 7.8 s |
| Mercedes-Benz S 350 CDi BlueEfficiency | 2011 | 173 kW | 2987 ccm | 250 km/h | 7.8 s |
| Mercedes-Benz S 350 CDi BlueEfficiency L | 2011 | 174 kW | 2987 ccm | 250 km/h | 7.8 s |
| Mercedes-Benz S 350 L | 2011 | 201 kW | 3498 ccm | 250 km/h | 7.3 s |
| Mercedes-Benz S 400 Hybrid | 2011 | 206 kW | 3496 ccm | 250 km/h | 7.2 s |
| Mercedes-Benz S 400 Hybrid L | 2011 | 206 kW | 3498 ccm | 250 km/h | 7.5 s |
| Mercedes-Benz S 450 | 2011 | 251 kW | 4663 ccm | 250 km/h | 5.9 s |
| Mercedes-Benz S 450 4Matic | 2011 | 251 kW | 4663 ccm | 250 km/h | 5.9 s |
| Mercedes-Benz S 450 4Matic L | 2011 | 251 kW | 4663 ccm | 250 km/h | 5.9 s |
| Mercedes-Benz S 450 CDi | 2011 | 236 kW | 3996 ccm | 250 km/h | 6.6 s |
| Mercedes-Benz S 450 CDi L | 2011 | 236 kW | 3996 ccm | 245 km/h | 6.6 s |
| Mercedes-Benz S 450 L | 2011 | 251 kW | 4663 ccm | 250 km/h | 5.9 s |
| Mercedes-Benz S 500 4Matic | 2011 | 286 kW | 5459 ccm | 250 km/h | 5.4 s |
| Mercedes-Benz S 500 4Matic L | 2011 | 286 kW | 5461 ccm | 250 km/h | 5.7 s |
| Mercedes-Benz S 500 L | 2011 | 286 kW | 5461 ccm | 245 km/h | 5.4 s |
| Mercedes-Benz S 550 | 2011 | 285 kW | 5461 ccm | - | - |
| Mercedes-Benz S 600 | 2011 | 381 kW | 5512 ccm | 250 km/h | 4.6 s |
| Mercedes-Benz S 63 AMG | 2011 | 400 kW | 5461 ccm | 250 km/h | 4.6 s |
| Mercedes-Benz S 65 AMG | 2011 | 464 kW | 5980 ccm | - | - |
| Mercedes-Benz S 65 AMG L | 2011 | 451 kW | 5980 ccm | - | 4.4 s |
